UPDATE: The highly anticipated matchup between the San Francisco 49ers and the Indianapolis Colts is set for 5:15 PM PDT today, December 22, 2025, at Lucas Oil Stadium. This is a crucial game for both teams, with playoff implications hanging in the balance.
Fans can catch all the action live on ESPN, with Joe Buck providing play-by-play commentary alongside analyst Troy Aikman. If you don’t have cable, don’t worry! ESPN now offers ESPN Unlimited, allowing viewers to stream the game directly and gain access to over 47,000 live events annually.
For those looking to enhance their viewing experience, several platforms enable live streaming while betting in real time. Caesars Sportsbook features its “Watch & Bet” tool, letting users follow the game and place bets simultaneously. Simply open the Caesars app, select the matchup, and experience the game like never before.
Canadian viewers can turn to bet365, which provides a seamless live streaming experience for NFL games. Registered users can watch and bet on the Colts vs. 49ers matchup directly from the app, provided they have placed a bet within the last 24 hours.
Additionally, BET99 delivers a full betting and viewing experience with its newly launched BetVision. Users can stream the game and access real-time stats—all on one screen—by placing either a pre-game or in-game bet to unlock live streaming.
This matchup is not just another game; it could determine playoff fates. A loss for the Colts could open the door for several AFC teams aiming for a postseason berth. Meanwhile, the 49ers are vying to maintain their position at the top of the competitive NFC West.
With the stakes higher than ever, football fans are urged to tune in and witness the drama unfold. Following the conclusion of the game, fans can listen to the action on national feeds from Westwood One Sports and SiriusXM NFL Radio.
As the clock ticks down to kickoff, make sure you have your streaming options ready. This is a must-watch event for NFL enthusiasts everywhere—don’t miss out on the excitement!
